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J Antimicrob Chemother. 2007 Jun;59(6):1182-4. Epub 2007 Apr 21.

Resveratrol inhibition of Propionibacterium acnes.

Author information

1
Department of Microbiology, Immunology and Biochemistry, Northeastern Ohio Universities College of Medicine, Rootstown, OH 44272, USA. jjd@neoucom.edu

Abstract

OBJECTIVES:

To evaluate the effects of the anti-inflammatory hydroxystilbene, resveratrol, on Propionibacterium acnes growth.

METHODS:

Three different strains of P. acnes were tested against resveratrol at concentrations between 0 and 200 mg/L. Piceatannol was included as a second hydroxystilbene to compare with resveratrol, and erythromycin and benzoyl peroxide were used as positive controls.

RESULTS:

After 24 h of treatment with resveratrol, the average 50% inhibitory concentration (IC(50)) was 73 mg/L and the average 100% inhibitory concentration (IC(100)) was 187 mg/L for the three strains of P. acnes tested. The IC(50) and IC(100) of piceatannol were 123 and 234 mg/L, respectively. The highest concentration of resveratrol tested (200 mg/L) was bactericidal, whereas lower concentrations were bacteriostatic.

CONCLUSIONS:

Resveratrol, an anti-inflammatory hydroxystilbene, is capable of inhibiting P. acnes growth.

PMID:
17449884
DOI:
10.1093/jac/dkm099
[Indexed for MEDLINE]

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