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Bioorg Med Chem Lett. 2007 Jun 15;17(12):3339-43. Epub 2007 Apr 6.

Discovery and optimization of a series of quinazolinone-derived antagonists of CXCR3.

Author information

1
Amgen Inc., 1120 Veterans Boulevard, South San Francisco, CA 94080, USA.

Abstract

A series of quinazolinone-derived inhibitors of the CXCR3 receptor have been synthesized and their affinity for the receptor evaluated. Compounds were evaluated in a (125)I-IP10 displacement assay and in in vitro cell migration assays to IP10, ITAC, and MIG using human peripheral blood mononuclear cells.

PMID:
17448658
DOI:
10.1016/j.bmcl.2007.03.106
[Indexed for MEDLINE]

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