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Neoplasma. 2007;54(3):207-11.

Expression of zinc-fingers and homeoboxes 2 in hepatocellular carcinogenesis: a tissue microarray and clinicopathological analysis.

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Department of Pathology, First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, China.


Zinc-fingers and homeoboxes 2 (ZHX2) is a novel transcriptional repressor. ZHX2 protein expression and its clinicopathological significance in hepatocellular carcinoma (HCC) remain largely unknown. The aim of this study was to analyze ZHX2 protein expression in a range of liver tissues obtained from cholangitis, cirrhosis, adjacent non-tumorous tissues, primary HCC tissues, and matched metastatic lesions by using Tissue microarray (TMA) technology and compare our findings with clinicopathological parameters. ZHX2 protein expression was detected only in HCC tissues. ZHX2 expression was associated with clinical stage of the disease. The rate of ZHX2 expression was approximately twice as high in stage III-IV (31.25%) compared with stage I-II (16.5%). These results demonstrated that ZHX2 protein may take part in hepatocellular carcinogenesis and HCC progression. In addition, ZHX2 expression in primary lesions with metastasis was significantly higher than without metastasis. ZHX2 expression in metastatic lesions (45.5%) was as approximately twice as higher than that in primary lesions (24.2%) from the same patient. According to these results, ZHX2 was associated with metastasis in HCC.

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