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Org Lett. 2007 May 10;9(10):1855-8. Epub 2007 Apr 21.

Combinatorial mutasynthesis of flavonoid analogues from acrylic acids in microorganisms.

Author information

1
State University of New York at Buffalo, Department of Chemical and Biological Engineering, 303 Furnas Hall, Buffalo, NY 14260, USA.

Abstract

Flavonoids are plant secondary metabolites often used as nutraceutical supplements, but a growing number of unnatural flavonoids are being investigated as therapeutic agents. Cultures of Saccharomyces cerevisiae expressing recombinant flavonoid enzymes, including 4-coumaroyl:CoA ligase (4CL), chalcone synthase (CHS), chalcone isomerase (CHI), and flavanone 3beta-hydroxylase (FHT), produced novel flavanones and dihydroflavonols when fed with a number of aromatic acrylic acids. The flavonoid network also exhibited broad substrate specificity by converting muconic acid into a unique polypropanoid.

PMID:
17447772
DOI:
10.1021/ol0703736
[Indexed for MEDLINE]

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