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Ann N Y Acad Sci. 2007 Mar;1099:361-72.

Regulation of Na+/Ca2+ exchange current in the normal and failing heart.

Author information

  • 1Institute of Neurophysiology, University of Cologne, D-50931 Cologne, Germany. akp72@uni-koeln.de

Abstract

Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na+ and Ca2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.

PMID:
17446476
DOI:
10.1196/annals.1387.065
[PubMed - indexed for MEDLINE]
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