Format

Send to

Choose Destination
See comment in PubMed Commons below
Science. 2007 Apr 20;316(5823):400-1.

The mysteries of sexual identity. The germ cell's perspective.

Author information

  • 1Howard Hughes Medical Institute, Department of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706, USA. jekimble@wisc.edu

Abstract

Animal germ cells differentiate as sperm or eggs, depending on their sex. Somatic signals tell germ cells whether they reside in a male or female body, but how do germ cells interpret those external cues to acquire their own sexual identity? A critical aspect of a germ cell's sexual puzzle is that the sperm/egg decision is closely linked to the cell-cycle decision between mitosis and meiosis. Molecular studies have begun to tease apart the regulators of both decisions, an essential step toward understanding the regulatory logic of this fundamental question of germ cell biology.

PMID:
17446389
DOI:
10.1126/science.1142109
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Support Center