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Eur J Pediatr. 2008 Apr;167(4):461-3. Epub 2007 Apr 19.

Intracranial aneurysm associated with chronic mucocutaneous candidiasis.

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Infectious Diseases Department, Giannina Gaslini Institute, University of Genoa, Largo Gerolamo Gaslini, 5-16147, Genoa, Italy.


Chronic mucocutaneous candidiasis (CMC) is a syndrome characterised by immune deficiency, often presenting familial dominant inheritance and association with autoimmune endocrinopathies. We report on a patient with CMC who died at 5 years of age of a brain haemorrhage following the rupture of a basilar-artery aneurysm. Candida hyphae in the basilar artery were found at autopsy. A common immunologic abnormality in CMC is the failure of patient's T-lymphocytes to produce cytokines, which are essential for expression of cell-mediated immunity to Candida. Therefore, long-term treatment is mandatory.

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