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Proc Natl Acad Sci U S A. 2007 May 1;104(18):7652-7. Epub 2007 Apr 18.

Patterning of frontal cortex subdivisions by Fgf17.

Author information

1
Medical Scientist Training Program, University of California, San Francisco, CA 94143-2611, USA.

Abstract

The frontal cortex (FC) is the seat of higher cognition. The genetic mechanisms that control formation of the functionally distinct subdivisions of the FC are unknown. Using a set of gene expression markers that distinguish subdivisions of the newborn mouse FC, we show that loss of Fgf17 selectively reduces the size of the dorsal FC whereas ventral/orbital FC appears normal. These changes are complemented by a rostral shift of sensory cortical areas. Thus, Fgf17 functions similar to Fgf8 in patterning the overall neocortical map but has a more selective role in regulating the properties of the dorsal but not ventral FC.

PMID:
17442747
PMCID:
PMC1863435
DOI:
10.1073/pnas.0702225104
[Indexed for MEDLINE]
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