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Sleep Med Rev. 2007 Jun;11(3):163-78. Epub 2007 Apr 17.

The metabolic consequences of sleep deprivation.

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1
Department of Medicine, University of Chicago, 5841 S. Maryland Ave, MC 1027, Chicago, IL 60637, USA. kknutson@health.bsd.uchicago.edu

Abstract

The prevalence of diabetes and obesity is increasing at an alarming rate worldwide, and the causes of this pandemic are not fully understood. Chronic sleep curtailment is a behavior that has developed over the past 2-3 decades. Laboratory and epidemiological studies suggest that sleep loss may play a role in the increased prevalence of diabetes and/or obesity. Current data suggest the relationship between sleep restriction, weight gain and diabetes risk may involve at least three pathways: (1) alterations in glucose metabolism; (2) upregulation of appetite; and (3) decreased energy expenditure. The present article reviews the current evidence in support of these three mechanisms that might link short sleep and increased obesity and diabetes risk.

PMID:
17442599
PMCID:
PMC1991337
DOI:
10.1016/j.smrv.2007.01.002
[Indexed for MEDLINE]
Free PMC Article

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