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Bioorg Med Chem Lett. 2007 Jun 15;17(12):3335-8. Epub 2007 Apr 5.

Benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides as inhibitors of carbonic anhydrase.

Author information

1
Laboratory of Biothermodynamics and Drug Design, Institute of Biotechnology, Vilnius LT-02241, Lithuania.

Abstract

A series of benzimidazo[1,2-c][1,2,3]thiadiazole-7-sulfonamides were synthesized and their binding to two carbonic anhydrase isozymes measured by isothermal titration calorimetry (ITC). Human carbonic anhydrase I (hCAI) and bovine carbonic anhydrase II (bCAII) bound the inhibitors with observed association constants in the range from 1.1 x 10(6) to 2.6 x 10(7) M(-1).

PMID:
17442568
DOI:
10.1016/j.bmcl.2007.03.100
[Indexed for MEDLINE]

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