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J Neurochem. 2007 Jul;102(2):316-23. Epub 2007 Apr 17.

Mechanisms of axon guidance: membrane dynamics and axonal transport in semaphorin signalling.

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Developmental Biology Institute of Marseille Luminy, CNRS UMR 6216, Université de la Méditerranée, Parc Scientifique de Luminy, Marseille cedex, France.

Abstract

The intricate geometry of neuronal networks poses many unique cell-biological problems regarding the way a growing axon responds to its environment. Several groups of ligand-receptor pairs have been identified to regulate such processes. In this study, we take class 3 semaphorins as an example and review what is known about the intracellular movements of semaphorins throughout neuronal cells, transport support structures and location of release sites. We discuss how their receptor trafficking may contribute to regulate membrane dynamics underlying growth cone motility and the physiological contribution made by class 3 semaphorins-induced acceleration of axoplasmic transport on neurite development.

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