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Nat Immunol. 2007 May;8(5):441-4.

Cell lineage regulators in B and T cell development.

Author information

1
Division of Biology, 156-29, California Institute of Technology, Pasadena, California 91125, USA. evroth@its.caltech.edu

Abstract

This special issue highlights a pivotal set of regulatory molecules that have emerged as central controllers of cell-type identity in the immune system. Each in its own way has been considered as a kind of 'master' regulator of a particular cell fate choice, but the actual modes of action of these factors vary widely. The comparison among them sheds light on the different ways that an essential regulatory input can affect cellular identity.

PMID:
17440447
DOI:
10.1038/ni1461
[Indexed for MEDLINE]

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