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Plast Reconstr Surg. 2007 May;119(6):1874-81.

Neurodevelopment of infants with single-suture craniosynostosis: presurgery comparisons with case-matched controls.

Author information

1
Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA, USA. mspeltz@u.washington.edu

Abstract

BACKGROUND:

The hypothesized association between single-suture craniosynostosis and neurodevelopment remains unclear, given the methodologic limitations of previous studies, most notably the absence of control groups.

METHODS:

Standardized measures were used to assess the neurodevelopment of 125 matched case-control pairs shortly after cases were first diagnosed with isolated fusions of the sagittal, metopic, lambdoid, or right or left coronal sutures. Participants varied in age from 2 to 24 months.

RESULTS:

Cases had significantly lower mean standardized scores than controls on measures of cognitive ability and motor functioning (p < 0.02). These differences were unaffected by the location of synostosis, age of diagnosis, infant sex, and maternal IQ. Measures of early language functions revealed no group differences.

CONCLUSIONS:

Before cranioplasty, single-suture craniosynostosis is associated with modest but reliable neurodevelopmental delays that cannot be attributed to maternal intelligence and family sociodemographic variables. Follow-up of this sample will determine the predictive significance of these delays. In the meantime, routine neurodevelopmental screening of infants with isolated craniosynostosis is recommended.

[Indexed for MEDLINE]
Free PMC Article

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