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J Addict Dis. 2007;26(1):15-26.

Correlation between high methadone doses and methadone serum levels in methadone maintenance treatment (MMT) patients.

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1
Tel-Aviv Elias Sourasky Medical Center, 6, Weizman St, Tel-Aviv, Israel.

Abstract

AIMS:

To evaluate the relation between high methadone doses and methadone serum levels in MMT patients.

DESIGN:

One hundred fifty-one steady methadone-dose patients were evaluated for methadone serum levels using GCMS. Urine samples during the month prior to the study-day were analysed and defined as positive if any sample was positive for any drug.

FINDINGS:

Methadone dose correlated with methadone serum levels (Pearson R = 0.36, P < 0.0005). In 53 patients with no drug abuse, correlation was stronger (R = 0.53, P < 0.0005) than in 98 patients with any drug abuse (R = 0.25, P = 0.01).

CONCLUSIONS:

We extended the well-established correlation between methadone doses and serum levels in patients receiving low or moderate (60 to 120 mg/day) to high methadone doses (up to 290 mg/day).

PMID:
17439864
DOI:
10.1300/J069v26n01_03
[Indexed for MEDLINE]
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