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Nat Rev Immunol. 2007 May;7(5):329-39.

Prospects for the use of NK cells in immunotherapy of human cancer.

Author information

1
Centre for Infectious Medicine, Department of Medicine, Karolinska Institute, Karolinska University Hospital Huddinge, 141 86 Stockholm, Sweden. hans-gustaf.ljunggren@ki.se

Abstract

Current insights into the molecular specificities that regulate natural killer (NK)-cell function suggest that it might be possible to design NK-cell-based immunotherapeutic strategies against human cancer. Here, we describe evidence for NK-cell targeting of human tumours and address crucial questions that, in our opinion, require consideration for the development of successful NK-cell-based therapies. Appropriately used, we predict that NK cells will have a role, both directly and in combination with other treatment modalities, in future treatment of cancer.

PMID:
17438573
DOI:
10.1038/nri2073
[Indexed for MEDLINE]

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