Format

Send to

Choose Destination
Clin Pharmacol Ther. 2007 May;81(5):631-3.

Grapefruit juice, a glass full of drug interactions?

Author information

1
Department of Pharmaceutics, University of Washington, Seattle, Washington, USA.

Abstract

Numerous reports have documented drug interactions with grapefruit juice (GFJ) that occur via inhibition of CYP3A enzymes. As reported by Glaeser et al. in the March 2007 issue of this journal, there is increasing recognition that GFJ may also affect the activity of influx (e.g., OATPs) and efflux (e.g., P-glycoprotein) transporters. This commentary focuses on these interactions between GFJ and drug transporters.

PMID:
17438537
DOI:
10.1038/sj.clpt.6100185
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center