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Antimicrob Agents Chemother. 2007 Jun;51(6):2274-7. Epub 2007 Apr 16.

Prophylactic effect of dietary seaweed Fucoidan against enteral prion infection.

Author information

1
Department of Prion Research, Tohoku University Graduate School of Medicine, 2-1 Seiryo-cho, Aoba-ku, Sendai, Miyagi 980-8575, Japan. doh-ura@mail.tains.tohoku.ac.jp

Abstract

Dietary seaweed fucoidan delays the onset of disease of enterally infected mice with scrapie when given orally for 6 days after infection, but not when given before the infection. This effect was not modified at a tested fucoidan dose range and appeared to reach the maximum level at a concentration of 2.5% or less in feed. Daily uptake of fucoidan might be prophylactic against prion diseases caused by ingestion of prion-contaminated materials, although further evaluation of its pharmacology remains to be done.

PMID:
17438058
PMCID:
PMC1891374
DOI:
10.1128/AAC.00917-06
[Indexed for MEDLINE]
Free PMC Article

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