Format

Send to

Choose Destination
See comment in PubMed Commons below
Nat Rev Microbiol. 2007 May;5(5):343-54.

DNA replication initiation: mechanisms and regulation in bacteria.

Author information

1
Department of Molecular and Cell Biology, Quantitative Biology Institute, University of California, Berkeley, 237 Hildebrand Hall #3220, California 94720-3220, USA.

Abstract

In all organisms, multi-subunit replicases are responsible for the accurate duplication of genetic material during cellular division. Initiator proteins control the onset of DNA replication and direct the assembly of replisomal components through a series of precisely timed protein-DNA and protein-protein interactions. Recent structural studies of the bacterial protein DnaA have helped to clarify the molecular mechanisms underlying initiator function, and suggest that key structural features of cellular initiators are universally conserved. Moreover, it appears that bacteria use a diverse range of regulatory strategies dedicated to tightly controlling replication initiation; in many cases, these mechanisms are intricately connected to the activities of DnaA at the origin of replication. This Review presents an overview of both the mechanism and regulation of bacterial DNA replication initiation, with emphasis on the features that are similar in eukaryotic and archaeal systems.

PMID:
17435790
DOI:
10.1038/nrmicro1640
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Nature Publishing Group
    Loading ...
    Support Center