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Nat Genet. 2007 May;39(5):593-5. Epub 2007 Apr 15.

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.

Author information

1
Human Genome Laboratory, Department of Molecular and Developmental Genetics, Vlaams Instituut voor Biotechnologie (VIB), Leuven, Belgium.

Abstract

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

PMID:
17435759
DOI:
10.1038/ng2025
[Indexed for MEDLINE]

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