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J Biosci. 2007 Mar;32(2):299-307.

Chondroprotective potential of root extracts of Withania somnifera in osteoarthritis.

Author information

1
Interactive Research School for Health Affairs (IRSHA), Bhartiya Vidyapeeth Deemed University Medical College Campus, Dhankawadi, Pune 411043, India. vsumantran@gmail.com

Abstract

This is the first report describing two novel chondroprotective activities of aqueous extracts of Withania somnifera root powder.First,these extracts had a statistically significant,short-term chondroprotective effect on damaged human osteoarthritic cartilage matrix in 50% of the patients tested. Second,these extracts caused a significant and reproducible inhibition of the gelatinase activity of collagenase type 2 enzyme in vitro.

PMID:
17435322
DOI:
10.1007/s12038-007-0030-3
[Indexed for MEDLINE]
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