Format

Send to

Choose Destination
Genetics. 2007 Jun;176(2):1355-8. Epub 2007 Apr 15.

Loss-of-function alleles of the JIL-1 histone H3S10 kinase enhance position-effect variegation at pericentric sites in Drosophila heterochromatin.

Author information

1
Department of Biochemistry, Biophysics, and Molecular Biology Iowa State University Ames, Iowa 50011, USA.

Abstract

In this study we show that loss-of-function alleles of the JIL-1 histone H3S10 kinase act as enhancers of position-effect variegation at pericentric sites whereas the gain-of-function JIL-1(Su(var)3-1[3]) allele acts as a suppressor strongly supporting a functional role for JIL-1 in maintaining euchromatic chromatin and counteracting heterochromatic spreading and gene silencing.

PMID:
17435241
PMCID:
PMC1894597
DOI:
10.1534/genetics.107.073676
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center