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Bioorg Med Chem Lett. 2007 Jun 15;17(12):3344-8. Epub 2007 Apr 5.

Naphthyl piperazines with dual activity as 5-HT1D antagonists and 5-HT reuptake inhibitors.

Author information

1
Lilly SA, Avda. de la Industria, 30, 28108, Alcobendas, Madrid, Spain. bueno_ana_belen@lilly.com

Abstract

SAR around a known molecule with dual 5-HT(1D) antagonist and 5-HT(transporter) inhibitory activity has led to the discovery of molecules with improved dual activity and reduced cross-reactivity toward other aminergic receptors (5-HT(1B), alpha(1), and D(2)).

PMID:
17434731
DOI:
10.1016/j.bmcl.2007.03.101
[Indexed for MEDLINE]

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