Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochem Biophys Res Commun. 2007 Jun 1;357(2):531-6. Epub 2007 Apr 9.

Identification of disease-associated proteins by proteomic approach in ankylosing spondylitis.

Author information

1
Center of Medical Genetics, Department of Hematology, Peking University First Hospital, Peking University, No. 8, Xishiku Street, West District, Beijing 100034, China.

Abstract

Ankylosing spondylitis (AS) is a chronic systemic inflammatory disorder of the axial skeleton and shows significant inherited susceptibility. Auto-immune responses have been traditionally considered as a putative pathogenetic event in AS. However, no consistent self-antigen has been identified to responsible for the disorders in AS to this day. In this study, serum protein profiles of AS patients and healthy controls from a large Chinese AS family were investigated by two dimensional electrophoresis analysis. A group of four highly expressed protein spots was observed in all AS patients' profiles and subsequently identified as isoforms of haptoglobin precursor (pre-Hp) by ESI-Q-TOF MS/MS. Increased expression of haptoglobin precursor were also observed in sera of sporadic AS patients. Moreover, bioinformatics analysis revealed epitopes derived from haptoglobin precursor with high affinity binding to HLA-B( *)2705, a primary subtype associated with AS. These results indicate that pre-Hp may be involved in the pathogenesis of AS.

PMID:
17434140
DOI:
10.1016/j.bbrc.2007.03.179
[Indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Support Center