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J Am Acad Dermatol. 2007 Oct;57(4):683-9. Epub 2007 Apr 16.

Thymoma-associated multiorgan autoimmunity: a graft-versus-host-like disease.

Author information

1
Permanente Medical Group, Fremont, California, USA.

Abstract

Graft-versus-host disease (GVHD) is a T cell-mediated disease seen most commonly after hematopoietic stem cell transplantation. Rarely, a GVHD-like disease can be seen in patients with malignant thymoma. We describe a 50-year-old man with malignant thymoma who developed skin, liver, and intestinal manifestations similar to that seen in GVHD. We also review other reported cases of GVHD-like manifestations in the setting of thymoma and propose "thymoma-associated multiorgan autoimmunity" as a name for this novel disease. Specifically, thymoma-associated multiorgan autoimmunity is defined as a disease of the liver, intestine, or skin, which on histopathology resembles GVHD but is seen in the setting of malignant thymoma and not after hematopoietic stem cell transplantation.

PMID:
17433850
DOI:
10.1016/j.jaad.2007.02.027
[Indexed for MEDLINE]

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