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Semin Immunol. 2007 Jun;19(3):197-205. Epub 2007 Apr 11.

The E3 ubiquitin ligase Itch in T cell activation, differentiation, and tolerance.

Author information

1
Division of Cell Biololgy, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA. yuncail@liai.org

Abstract

Tagging a small molecule ubiquitin to a protein substrate, or protein ubiquitination, plays an important role in the immune responses. This process is catalyzed by a cascade of enzymatic reactions, with the E3 ubiquitin ligases being the critical enzymes that determine the specificity of substrate recognition. The E3 ligase Itch was identified from a mutant mouse which displays skin scratching and abnormal immune disorders. In the past few years, much progress has been made in our understanding of Itch-promoted protein ubiquitination, modulation of its ligase activity by upstream kinases, and the kinase-ligase interaction in T cell differentiation and tolerance induction.

PMID:
17433711
PMCID:
PMC2680672
DOI:
10.1016/j.smim.2007.02.003
[Indexed for MEDLINE]
Free PMC Article

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