Smallest peptoids with antiproliferative activity on human neoplastic cells

J Med Chem. 2007 May 17;50(10):2443-9. doi: 10.1021/jm061166z. Epub 2007 Apr 14.

Abstract

Libraries of new, small peptoid monomers and dipeptoids were synthesized and assayed for antiproliferative activity against representative human neoplastic cell lines. The C-terminal N-alkyl amide peptoids are cytotoxic and are the smallest peptoids reported to have such activity. These compounds were conveniently synthesized on a BAL resin. Owing to their structure, the peptoids did not suffer from DKP formation, a problematic side reaction typically observed in peptide and peptoid synthesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology
  • Cell Line, Tumor
  • Combinatorial Chemistry Techniques
  • Drug Screening Assays, Antitumor
  • Humans
  • Peptoids / chemical synthesis*
  • Peptoids / chemistry
  • Peptoids / pharmacology
  • Solubility
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Peptoids