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Eur J Clin Pharmacol. 1991;41(2):137-40.

Treatment of insomnia with two benzodiazepines: a double-blind crossover study.

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Department of Psychiatry and Behavioral Medicine, Ostmarka Hospital, University of Trondheim, Norway.


Twenty-eight patients (12 M, 16 F) with insomnia were treated with nitrazepam 5 mg/d and oxazepam 25 mg/d, each for 11 days, in a double-blind crossover comparison with placebo. Half the patients received nitrazepam in the first drug period, and oxazepam in the second and the other half followed the contrary sequence. Both nitrazepam and oxazepam were found to be effective in inducing sleep and increasing sleep quality. No effects on dreaming or adverse effects were found. Nitrazepam did influence the frequency of awakening, but only in the second drug period. In the first period it reduced self-waking. It is concluded that both nitrazepam and oxazepam were effective in inducing sleep and in improving sleep quality.

[Indexed for MEDLINE]

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