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HNO. 2007 May;55(5):399-402.

[Treatment of laryngeal movement disorders with botulinum toxins: part 1: History and mode of action].

[Article in German]

Author information

1
Klinik und Poliklinik für Phoniatrie und Pädaudiologie, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625, Hannover. schwemmle.cornelia@mh-hannover.de

Abstract

Laryngeal dystonia (spasmodic dysphonia) is a movement disorder characterised by involuntary contractions of the laryngeal muscles involved in vocalisation. The introduction of botulinum toxin (BTX) in the treatment of laryngeal dystonia had a major clinical impact due to the striking improvement of symptoms. Most patients with severe types of spasmodic dysphonia are treated with injections of botulinum toxin type A. For patients with a resistance against type A toxin there is a new hypercleaned type A toxin or type B available. Research on type F toxin is also underway. In this article, the history of botulinum toxin, its therapeutic activity and possibilities for its use are described.

PMID:
17431567
DOI:
10.1007/s00106-007-1553-5
[Indexed for MEDLINE]
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