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Science. 2007 Apr 13;316(5822):240-3.

Demographic histories and patterns of linkage disequilibrium in Chinese and Indian rhesus macaques.

Author information

1
Biological Statistics and Computational Biology, Cornell University, Ithaca, NY 14850, USA.

Abstract

To understand the demographic history of rhesus macaques (Macaca mulatta) and document the extent of linkage disequilibrium (LD) in the genome, we partially resequenced five Encyclopedia of DNA Elements regions in 9 Chinese and 38 captive-born Indian rhesus macaques. Population genetic analyses of the 1467 single-nucleotide polymorphisms discovered suggest that the two populations separated about 162,000 years ago, with the Chinese population tripling in size since then and the Indian population eventually shrinking by a factor of four. Using coalescent simulations, we confirmed that these inferred demographic events explain a much faster decay of LD in Chinese (r(2) approximately 0.15 at 10 kilobases) versus Indian (r(2) approximately 0.52 at 10 kilobases) macaque populations.

PMID:
17431170
DOI:
10.1126/science.1140462
[Indexed for MEDLINE]
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