Format

Send to

Choose Destination
Dermatol Surg. 2007 Apr;33(4):421-5; discussion 425-6.

Correlation of thickness of basal cell carcinoma by optical coherence tomography in vivo and routine histologic findings: a pilot study.

Author information

1
Department of Dermatology, Mayo Clinic, Scottsdale, Arizona 85259, USA.

Abstract

BACKGROUND:

Optical coherence tomography uses advanced photonics and fiber optics to obtain high-resolution cross-sectional images and tissue characterization in real time.

OBJECTIVE:

The objective was to correlate measurements of the depth of basal cell carcinomas obtained by optical coherence tomography and standard histopathologic examinations.

METHODS:

Twenty previously scanned optical coherence tomography images of histopathologically confirmed basal cell carcinoma were reviewed. A computer-generated depth scale was used to measure the depth of the neoplasm. These measurements were compared with direct measurements of tumor thickness of analogous tissue specimens made with a microscope micrometer.

RESULTS:

All 20 sites demonstrated excellent correlation of tissue thickness, to a depth of about 1 mm, estimated by optical coherence tomography or routine histopathologic tests. This depth correlation was consistent across several different types of basal cell carcinoma observed.

CONCLUSION:

Optical coherence tomography, compared with routine histopathologic techniques, shows promise as a method for estimating the superficial thickness of basal cell carcinoma.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wolters Kluwer
Loading ...
Support Center