Format

Send to

Choose Destination
Clin Exp Allergy. 2007 Apr;37(4):506-11.

Differences in the composition of intestinal Bifidobacterium species and the development of allergic diseases in infants in rural Japan.

Author information

1
Department of Pediatrics, Graduate School of Medicine Chiba University, Inohana, Chuo-ku, Chiba, Japan.

Abstract

BACKGROUND:

Bifidobacterium is a dominant genus in the intestinal microbiota of infants and comprises many different species. A series of studies performed in northern Europe showed differences in the composition of Bifidobacterium species between allergic infants and healthy controls. Additional studies are needed to confirm this observation.

OBJECTIVE:

To investigate the composition of fecal Bifidobacterium species in allergic infants and healthy controls in Japan, using molecular methods.

METHODS:

Full-term born babies were followed up to 6 months of age at a local hospital in rural Japan. The presence or absence of allergy was determined based on allergic symptoms and skin prick tests. Fecal Bifidobacterium species in allergic infants (n=10), and healthy controls (n=16) were evaluated using nine Bifidobacterium species-specific or group-specific primers based on 16S rDNA sequences at 1, 3, and 6 months of age.

RESULTS:

The number of the infants in whom no Bifidobacterium species could be found was four (15.4%) at 1 month, two (7.7%) at 3 months, and one (3.3%) at 6 months of age, all of whom were healthy controls. At 1 month of age, allergic infants had a higher prevalence f the Bifidobacterium catenulatum group than healthy controls (60.0% vs. 6.3%, P<0.01). At 6 months of age, allergic infants had a higher prevalence of B. bifidum than healthy controls (70.0% vs. 12.5%, P<0.01). These differences were not related to feeding method.

CONCLUSIONS:

Our results in infants in rural Japan support the hypothesis that a compositional difference in intestinal Bifidobacterium species may be associated with the development of allergy in early infancy, although the responsible species might vary among countries or races.

[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center