Outbreak of fungemia among neonates caused by Candida haemulonii resistant to amphotericin B, itraconazole, and fluconazole

J Clin Microbiol. 2007 Jun;45(6):2025-7. doi: 10.1128/JCM.00222-07. Epub 2007 Apr 11.

Abstract

The first outbreak of Candida haemulonii fungemia is described. The seven isolates from the blood of four neonates were identified by DNA sequencing of the ribosomal DNA. They were all resistant to amphotericin B, fluconazole, and itraconazole. This report highlights the emergence of C. haemulonii as an opportunistic pathogen in immunocompromised patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphotericin B / pharmacology
  • Antifungal Agents / pharmacology*
  • Candida / classification
  • Candida / drug effects*
  • Candidiasis / epidemiology
  • Candidiasis / microbiology
  • Disease Outbreaks*
  • Drug Resistance, Fungal*
  • Female
  • Fluconazole / pharmacology
  • Fungemia / epidemiology*
  • Fungemia / microbiology
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infant, Premature, Diseases / epidemiology*
  • Infant, Premature, Diseases / microbiology
  • Itraconazole / pharmacology
  • Male
  • Microbial Sensitivity Tests
  • Molecular Sequence Data
  • Sequence Analysis, DNA

Substances

  • Antifungal Agents
  • Itraconazole
  • Amphotericin B
  • Fluconazole

Associated data

  • GENBANK/AM231721
  • GENBANK/AM231722
  • GENBANK/AM231723
  • GENBANK/AM231724
  • GENBANK/AM231725
  • GENBANK/AM412999
  • GENBANK/AM413000