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Neurosci Res. 2007 Jul;58(3):332-5. Epub 2007 Mar 13.

Family-based association study between GRIK2 polymorphisms and autism spectrum disorders in the Korean trios.

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Department of Pharmacology, School of Medicine, Eulji University, Daejeon, Republic of Korea.


Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder with strong genetic components. The present study comprises the detection of four single nucleotide polymorphisms (SNPs) in GRIK2 followed by a family-based association analysis of the SNPs in 126 Korean ASD trios by using the transmission disequilibrium test (TDT) and haplotype analysis. We found preferential transmission of the C allele at the rs3213607 (P<0.001) of GRIK2 in ASD and haplotype analysis revealed that one haplotype demonstrated a significant association (P=0.023). These results suggest a potential association between GRIK2 and ASD in the Korean population.

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