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Bull Exp Biol Med. 2006 Sep;142(3):356-9.

Geroprotective effect of epithalamine (pineal gland peptide preparation) in elderly subjects with accelerated aging.

[Article in English, Russian]

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Institute of Gerontology, Academy of Medical Sciences of Ukraine, Kiev.


A 12-year randomized clinical study of epithalamine (pineal gland peptide preparation) was carried out in elderly patients with coronary disease and accelerated aging of the cardiovascular system. Long-term treatment with epithalamine decreased the functional age and degree of cardiovascular aging; exercise tolerance increased. After 12 years the number of elderly subjects dead in the group treated by epithalamine was 28% lower than in the control group, despite the same basic therapy. Cardiovascular mortality was 2-fold lower in patients treated by epithalamine; the incidence of cardiovascular failure and respiratory diseases was 2-fold lower in this group. Long-term treatment with epithalamine was associated with a geroprotective effect on the long-term life prognosis in elderly subjects with accelerated aging.

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