Oxidized forms of fibrinogen induce expression of cell adhesion molecules by cultured endothelial cells from human blood vessels

Bull Exp Biol Med. 2006 Sep;142(3):308-12. doi: 10.1007/s10517-006-0353-3.
[Article in English, Russian]

Abstract

Oxidized forms of fibrinogen similarly to initial non-oxidized fibrinogen induced expression of P-selectin and ICAM-1 cell adhesion molecules in the cultured endothelial cells derived from human umbilical vein. The effect of oxidized fibrinogen on the expression of adhesion molecules was more pronounced. These data attest to more active participation of oxidized forms of fibrinogen into inflammation in the vascular wall, the first stage of atherogenesis.

MeSH terms

  • Cells, Cultured
  • Endothelial Cells / drug effects*
  • Endothelial Cells / metabolism
  • Endothelium, Vascular / cytology
  • Fibrinogen / pharmacology*
  • Humans
  • Intercellular Adhesion Molecule-1 / metabolism*
  • Oxidation-Reduction
  • P-Selectin / metabolism*
  • Time Factors
  • Umbilical Veins / cytology*

Substances

  • P-Selectin
  • Intercellular Adhesion Molecule-1
  • Fibrinogen