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Diabetes Educ. 2007 Mar-Apr;33(2):257-8, 260, 262 passim.

The new indicator test (Neuropad): a valuable diagnostic tool for small-fiber impairment in patients with type 2 diabetes.

Author information

1
The Second Department of Internal Medicine, Democritus University of Thrace, Greece (Dr. Papanas, Dr. Papatheodorou, Dr. Papazoglou, Dr. Monastiriotis, Dr. Maltezos)
2
Diabetic Department, University Hospital of Alexandroupolis, Greece (Dr. Christakidis)

Abstract

PURPOSE:

The purpose of this study was to evaluate the new indicator test for sudomotor function (Neuropad) in the diagnosis of small-fiber impairment in patients with type 2 diabetes.

METHODS:

This study included 123 patients with type 2 diabetes (59 men; mean age, 64.3 +/- 8.6 years; mean diabetes duration, 12 +/- 6.1 years). Sudomotor dysfunction was assessed by means of the new indicator test. Neuropathy was diagnosed by the Neuropathy Disability Score and small-fiber impairment by temperature perception (Tiptherm device) and pain perception (Neurotip).

RESULTS:

The frequency of sudomotor dysfunction was significantly (P = .001) higher in patients with neuropathy (95%) than in those without neuropathy (30.2%). Sensitivity of the indicator test for neuropathy was 95%, and specificity was 69.8%. Frequency of neuropathy was significantly (P = .018) higher with the indicator test (74.8%) than with conventional clinical examination (65.4%). Sudomotor dysfunction was significantly (P = .001) more frequent in patients with small-fiber impairment (99%) than in those without small-fiber impairment (21.7%). Sensitivity for small-fiber impairment was 99%, and specificity was 78.3%. There was no difference (P = .999) in the frequency of small-fiberimpairment as diagnosed with the indicator test (80.5%) and with clinical examination (81.3%).

CONCLUSIONS:

The indicator test has a very high sensitivity and specificity for small-fiber impairment in patients with type 2 diabetes.

PMID:
17426301
DOI:
10.1177/0145721707299661
[Indexed for MEDLINE]

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