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Physiology (Bethesda). 2007 Apr;22:113-21.

The ins and outs of secretion from pancreatic beta-cells: control of single-vesicle exo- and endocytosis.

Author information

1
Department of Pharmacology, University of Alberta, Edmonton, Alberta, Canada. pmacdonald@bcell.org

Abstract

Exocytosis of insulin-containing secretory vesicles in pancreatic beta-cells is crucial to maintenance of plasma glucose levels. They fuse with the plasma membrane in a regulated manner to release their contents and are subsequently recaptured either intact or through conventional clathrin-mediated endocytosis. Here, we discuss these mechanisms in beta-cells at the single-vesicle level.

PMID:
17420302
DOI:
10.1152/physiol.00047.2006
[Indexed for MEDLINE]
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