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Dev Cell. 2007 Apr;12(4):484-5.

Reactive oxygen species regulate autophagy through redox-sensitive proteases.

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1
Laboratory of Immunology, NIAID, NIH, Building 10, Room 11N311, 10 Center Drive, MSC 1892, Bethesda, MD 20892, USA. liuzhi@niaid.nih.gov

Abstract

Starvation induces autophagy through a signal transduction pathway that is not fully understood. In a recent issue of The EMBO Journal, Scherz-Shouval and colleagues (Scherz-Shouval et al., 2007) show that reactive oxygen species (ROS) occurring during starvation serve as signaling molecules that initiate autophagy.

PMID:
17419989
DOI:
10.1016/j.devcel.2007.03.016
[Indexed for MEDLINE]
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