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Dev Cell. 2007 Apr;12(4):475-7.

The centrosome opens the way to mitosis.

Author information

1
Wellcome Trust/Cancer Research UK Gurdon Institute, Tennis Court Road, Cambridge, CB2 1QR United Kingdom. r.basto@gurdon.cam.ac.uk

Abstract

During mitosis, the interaction between chromosomes and microtubules requires nuclear envelope disassembly in prophase. Two articles in this issue of Developmental Cell show that centrosomes have a role in promoting nuclear envelope breakdown (Hachet et al., 2007; Portier et al., 2007). Surprisingly, the role of the centrosome in this process is independent of its role as a microtubule nucleation organelle. Instead, the centrosome seems to act as a spatial regulator for the activation of the Aurora A kinase.

PMID:
17419985
DOI:
10.1016/j.devcel.2007.03.012
[Indexed for MEDLINE]
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