[Research advance of role of inhibitor of differentiation 2 in skeletal muscle regeneration]

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2007 Mar;21(3):307-10.
[Article in Chinese]

Abstract

Objective: To review researches of the role of inhibitor of differentiation 2(Id2) in skeletal muscle regeneration.

Methods: The latest original literature concerning Id2 and its role in skeletal muscle regeneration was extensively reviewed.

Results: Id2 could form heterodimers by combining with E protein to prevent myogenic regulatory factors (MRFs) forming heterodimers by combining with E protein, to inhibit the transcription activity of MRFs and differentiation of skeletal muscle cell.

Conclusion: Id2 plays an important role in skeletal muscle regeneration.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Cell Proliferation
  • Humans
  • Inhibitor of Differentiation Protein 2 / physiology*
  • Mice
  • Muscle, Skeletal / cytology
  • Muscle, Skeletal / injuries
  • Muscle, Skeletal / physiology*
  • Myoblasts / cytology
  • Myoblasts / physiology
  • Myogenic Regulatory Factors / antagonists & inhibitors*
  • Regeneration*

Substances

  • Inhibitor of Differentiation Protein 2
  • Myogenic Regulatory Factors