Format

Send to

Choose Destination
Biomol Eng. 2007 Jun;24(2):169-77. Epub 2007 Mar 13.

Modificomics: posttranslational modifications beyond protein phosphorylation and glycosylation.

Author information

1
University of Wuerzburg, Proteomics Group, Pharmaceutical Biology, Julius-von-Sachs-Institute for Biosciences, Julius-von-Sachs-Platz 2, 97082 Wuerzburg, Germany.

Abstract

Posttranslational modifications of proteins possess key functions in the regulation of various cellular processes. While they facilitate fast, location-specific and transient reactions to changing conditions in the first place they enhance the already high complexity of a cellular proteome by orders of magnitude. Furthermore, they can utterly alter the properties of the modified protein, thus making a timely analysis even more difficult. While several standardized methods for the analysis of protein phosphorylation and glycosylation have been established most other modifications require tailor-made solutions for a comprehensive analysis. Therefore, we will provide guidelines for the analysis of some important posttranslational modifications that are underrepresented in contemporary literature.

PMID:
17419095
DOI:
10.1016/j.bioeng.2007.03.002
[Indexed for MEDLINE]

Supplemental Content

Loading ...
Support Center