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Semin Nephrol. 2007 Mar;27(2):153-60.

Regulation of transforming growth factor beta in diabetic nephropathy: implications for treatment.

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1
Center for Novel Therapies in Kidney Disease, Dorrance Hamilton Research Laboratories, Division of Nephrology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA.

Abstract

The recognition that the drivers of matrix accumulation is an appropriate therapeutic target for diabetic nephropathy is now accepted by the nephrology and pharmaceutical communities. Interventions focused around transforming growth factor-beta (TGF-beta) likely will be an important area of clinical investigation in the near future. Understanding the various pathways involved in stimulating TGF-beta in the diabetic kidney is of paramount importance in devising strategies to combat the development and progression of diabetic nephropathy. In this review we highlight the major pathways involved in stimulating TGF-beta production by increased glucose levels and discuss the therapeutic implications thereof.

PMID:
17418684
PMCID:
PMC1948024
DOI:
10.1016/j.semnephrol.2007.01.008
[Indexed for MEDLINE]
Free PMC Article
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