Format

Send to

Choose Destination
Curr Opin Pharmacol. 2007 Jun;7(3):244-51. Epub 2007 Apr 5.

Opportunistic infections in lung disease: Pseudomonas infections in cystic fibrosis.

Author information

1
Department of Pediatrics, College of Physicians & Surgeons, Columbia University, New York, NY 10032, USA.

Abstract

Pseudomonas aeruginosa is an opportunistic pathogen that significantly contributes to morbidity and mortality in patients with cystic fibrosis. Defective mucociliary clearance associated with the absence of the functional cystic fibrosis transmembrane conductance regulator in airway epithelium plays a critical role in the initial colonization of this pathogen. P. aeruginosa, while initiating a profound inflammatory response, employs multiple mechanisms to evade immune clearance. The capacity to grow in biofilms and the selection of mutants with a mucoid phenotype are major adaptations that allow its persistence in the airways.

PMID:
17418640
DOI:
10.1016/j.coph.2006.12.005
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center