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Nat Struct Mol Biol. 2007 May;14(5):449-51. Epub 2007 Apr 8.

Bluetongue virus VP4 is an RNA-capping assembly line.

Author information

1
Division of Structural Biology, The Wellcome Trust Centre for Human Genetics, University of Oxford, Roosevelt Drive, Headington, Oxford, OX3 7BN, UK.

Abstract

Eukaryotic organisms cap the 5' ends of their messenger RNAs by a series of four chemical reactions. Some viruses achieve this using a single molecule; the crystal structure of such an enzyme from bluetongue virus reveals an elongated modular architecture that provides a scaffold for an assemblage of active sites, two contributed by a domain of novel structure.

PMID:
17417654
DOI:
10.1038/nsmb1225
[Indexed for MEDLINE]

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