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Nat Neurosci. 2007 May;10(5):543-5. Epub 2007 Apr 8.

CLOCK and NPAS2 have overlapping roles in the suprachiasmatic circadian clock.

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1
Department of Neurobiology, University of Massachusetts Medical School, 364 Plantation Street, Worcester, Massachusetts 01605, USA.

Abstract

Heterodimers of CLOCK and BMAL1, bHLH-PAS transcription factors, are believed to be the major transcriptional regulators of the circadian clock mechanism in mammals. However, a recent study shows that CLOCK-deficient mice continue to exhibit robust behavioral and molecular rhythms. Here we report that the transcription factor NPAS2 (MOP4) is able to functionally substitute for CLOCK in the master brain clock in mice to regulate circadian rhythmicity.

PMID:
17417633
PMCID:
PMC2782643
DOI:
10.1038/nn1884
[Indexed for MEDLINE]
Free PMC Article
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