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Trends Microbiol. 2007 Jun;15(6):252-6. Epub 2007 Apr 9.

MgtC: a key player in intramacrophage survival.

Author information

1
Inserm, Espri 26, Avenue J.F. Kennedy, 30908 Nîmes cedex 02, France.

Abstract

Several bacterial pathogens have evolved strategies to survive in macrophages and create a replicative niche within phagosomes. The bacterial factor MgtC is a key player in intramacrophage survival, being important for virulence in diverse intracellular pathogens. MgtC is also required for growth under magnesium limitation. Recent studies provide new clues on the role of MgtC in macrophages, which seems to be unlinked to adaptation to a low Mg(2+) microenvironment. In addition, we discuss the unexpected finding that MgtC modulates host P-type ATPase activity.

PMID:
17416526
DOI:
10.1016/j.tim.2007.03.007
[Indexed for MEDLINE]

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