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Comp Immunol Microbiol Infect Dis. 2007 Jul;30(4):225-46. Epub 2007 Apr 9.

Animal experimentation in Japan: regulatory processes and application for microbiological studies.

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Science and Technology Foresight Center, National Institute of Science and Technology Policy, Ministry of Education, Culture, Sports, Science and Technology, Japan.


We have conducted animal experimentation as a highly effective technique in biological studies. Also in microbiological studies, we have used experimentation to prevent and treat many infectious diseases in humans and animals. In Japan, the 'Law for the Humane Treatment and Management of Animals', which covers the consideration of the three R principles, refinement, replacement and reduction for an international humane approach to animal experimentation came into effect in June 2006. Looking towards the straightforward operation of the law in animal experimentation, three government ministries established new basic guidelines for experimentation performed in their jurisdictional research and testing facilities. For future microbiological studies involving animals in Japan, we need to perform animal experiments according to the basic guidelines in association with overseas management systems. In this report, we discussed essential actions for the management of animal experimentation in microbiological studies in Japan.

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