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Hum Genet. 2007 Jun;121(5):635-7. Epub 2007 Apr 6.

The P239S palladin variant does not account for a significant fraction of hereditary or early onset pancreas cancer.

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Sam Minuk Cancer Genetics and Biomarker Laboratories, Samuel Lunenfeld Research Institute, Toronto, Ontario, Canada.

Erratum in

  • Hum Genet. 2007 Jul;121(6):767. Zogopoulous, George [corrected to Zogopoulos, George].


The P239S palladin variant has recently been suggested to play a role in hereditary pancreatic cancer. We estimated the contribution of the P239S variant, and surrounding sequence, to familial and early-onset pancreatic cancer. The P239S germline variant was identified in one of 84 high-risk cases and one of 555 controls. The case reported an elderly relative with pancreas cancer. We conclude that this variant does not appear to account for a significant fraction of hereditary or early-onset pancreas cancer.

[Indexed for MEDLINE]

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