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MedGenMed. 2006 Nov 22;8(4):39.

Effects of an 8-week high-protein or high-carbohydrate diet in adults with hyperinsulinemia.

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1
Department of Nutrition, Arizona State University, Mesa, Arizona, USA.

Abstract

CONTEXT:

Incidence of insulin resistance (IR) in Americans is steadily rising. IR may be ameliorated with < or = 5% loss in body weight.

OBJECTIVE:

To examine effects of 2 weight-loss diets on body weight and composition in overweight adults with IR.

DESIGN:

Participants randomly assigned to a high-protein, low-fat (HPLF) or a high-carbohydrate, low-fat (HCLF) diet for 8 weeks.

SETTING:

All meals prepared and weighed in the metabolic kitchen at Arizona State University. Lunch consumed on-site; all other meals packaged for home consumption.

PATIENTS:

Twenty overweight, healthy participants with elevated fasting serum insulin (> or = 15 microU/L) were recruited.

INTERVENTIONS:

Both diets were low-fat (27% kcal from fat; < 7% saturated, < or = 10% monounsaturated, and < or = 10% polyunsaturated) and energy-restricted (energy levels were 1200, 1500, 1700 or 2000 kcal); HPLF: 32% protein, 41% carbohydrate; HCLF: 59% carbohydrate, 14% protein. Energy levels were assigned on the basis of participant's resting metabolic rate.

MAIN OUTCOME MEASURES:

Body composition, etabolic indices, fasting plasma glucose, and insulin.

RESULTS:

No significant differences were found in the main outcome measures between the diets. Body weight (HPLF: -4.9 kg; HCLF: -4.0 kg) and total percent body fat (HPLF: -1.5%; HCLF: -0.4%) significantly reduced from baseline to week 8 (P = .005 and P = .035, respectively).

CONCLUSION:

Both diets promoted > or = 5% loss in body weight and significantly reduced percent body fat.

PMID:
17415320
PMCID:
PMC1868379
[Indexed for MEDLINE]
Free PMC Article
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