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AIDS. 2007 Apr 23;21(7):871-3.

Primary genotypic resistance of HIV-1 to the maturation inhibitor PA-457 in protease inhibitor-experienced patients.

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1
Laboratoire de Virologie, Université Pierre et Marie Curie (Paris 6), France.

Abstract

Sequences from 82 protease inhibitors (PI)-experienced patients were analysed for the presence of previously described in-vitro resistance mutations to PA-457 located in the C-terminal capside (H226Y, L231F, L231M) and in the N-terminal SP1 (A1V, A3T, A3V) within the CA-SP1 boundary domain. Overall, the CA-SP1 cleavage site was highly conserved in PI pre-treated patients and only one patient showed an L231M mutation. The impact of this mutation should be further addressed in vivo.

PMID:
17415044
DOI:
10.1097/QAD.0b013e3280b079d9
[Indexed for MEDLINE]
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